Ciprofloxacin on Burned Patients

A Population Pharmacokinetics Study of Plasma Levels of Ciprofloxacin Following a Regimen of Repeated Dose I.V. Administration (400 mg TID) on Burn Patients

This was a non randomised, multi center, italian study performed in burn patients receiving an antibiotic (ciprofloxacin) in order to treat an active infection. The aim of the study was to validate a pharmacokinetics model useful to verify if a standard dose regimen of ciprofloxacin, given to patients with a compromised metabolism, is a correct dose or instead is over or under dosed.

Inclusion Criteria:

• Moderate to severe burnt patients defined as burning of 20 to 60% of total body surface according to rule of nine, II deep degree and III degree according to Full-Thickness Burn model,
• Hospitalization for burning injury since at least 72h during hyper metabolic phase
• Active infections microbiological confirmed
• Signed informed consent

Exclusion Criteria:

• Pregnant or lactating female patients
• Previous history of tendinopathy
• Knowing syndrome of QTc prolongation
• Impairment renal function
• Hepatic insufficiency
• Convulsion
• Limited life expectancy