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Sedation is widely used in mechanically ventilated patients. Propofol, benzodiazepines and opioids are the most used drugs. The study hypothesis is that sedation with remifentanil (an opioid drug) could improved respiratory pattern and effort in mechanically ventilated patients with rapid shallow breathing or high respiratory rate.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| treatment | Experimental | Any patient alternatively receive both remifentanil and isotonic saline (placebo)infusion. The order of infusion is randomized. An interval of 30 minutes is planned between the two infusions. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| remifentanil | Drug | 0.05 mcg.kg-1.min-1 for 30 minutes by continuous endovenous infusion |
| |
| Measure | Description | Time Frame |
|---|---|---|
| respiratory rate/tidal volume | before and after remifentanil infusion; before and after placebo infusion. | |
| pressure-time product | before and after remifentanil infusion; before and after placebo infusion. |
| Measure | Description | Time Frame |
|---|---|---|
| double product of respiratory system | before and after remifentanil infusion; before and after placebo infusion. | |
| dynamic intrinsic PEEP | before and after remifentanil infusion; before and after placebo infusion. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Giuseppe Natalini, MD | Fondazione Poliambulanza Istituto Ospedaliero | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Intensive Care Unit, Fondazione Poliambulanza Istituto Ospedaliero | Brescia | 25124 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21333087 | Derived | Natalini G, Di Maio A, Rosano A, Ferretti P, Bertelli M, Bernardini A. Remifentanil improves breathing pattern and reduces inspiratory workload in tachypneic patients. Respir Care. 2011 Jun;56(6):827-33. doi: 10.4187/respcare.01014. Epub 2011 Feb 11. |
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| ID | Term |
|---|---|
| D012131 | Respiratory Insufficiency |
| D053120 | Respiratory Aspiration |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D000077208 | Remifentanil |
| ID | Term |
|---|---|
| D011422 | Propionates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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| placebo |
| Drug |
NaCl 0.9 % |
|
| adverse events | during all the study period |
| arterial pH | before and after remifentanil infusion; before and after placebo infusion. |
| level of sedation (RASS) | before and after remifentanil infusion; before and after placebo infusion. |
| D010880 |
| Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |