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The purposes of the study are to analyse the cross-section data of secondary stroke prevention in China and to carry out a standard medical management including medicine and interactive education program,and to evaluate the efficacy and safety of the standard medical management in secondary stroke prevention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental |
| |
| 2 | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aspirin / Clopidogrel, Atorvastatin / Simvastatin | Drug | Standard Medical Management,including antiplatelet agents(Aspirin 75~150mg/day or Clopidogrel 75mg/day),statins(Atorvastatin 20mg/day or Simvastatin 20mg/day),risk factor lowering agents (antihypertension agents:Amlodipine 5mg/day or Benazepril 10mg/day or Valsartan 80mg/day or Nifedipine 30mg/day or Indapamide 2.5mg/day,antidiabetic agents: Metformin 0.5 tid or Glipizide 5mg tid or Acarbose 50mg tid )if necessary,interactive education program (Online medical education program, health behavior guide) . |
| Measure | Description | Time Frame |
|---|---|---|
| Success Rate of standard medical management | 1 year after enrolled |
| Measure | Description | Time Frame |
|---|---|---|
| Ischemic stroke | 1 year after enrolled | |
| Non-fatal acute coronary syndrome | 1 year after enrolled | |
| Transient Ischemic Attack |
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Inclusion Criteria:
Exclusion Criteria:
Patients will be excluded from entry if any of the criteria listed below are met
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| Name | Affiliation | Role |
|---|---|---|
| Liying Cui | Peking Union Medical College Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking Union Medical College Hosptial | Beijing | Beijing Municipality | 100730 | China | ||
| China Pla General Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31024430 | Derived | Cao Y, Zhang M, Zhou L, Yao M, Peng B, Zhu Y, Ni J, Cui L. Consecutive Slides on Axial View Is More Effective Than Transversal Diameter to Differentiate Mechanisms of Single Subcortical Infarctions in the Lenticulostriate Artery Territory. Front Neurol. 2019 Apr 9;10:336. doi: 10.3389/fneur.2019.00336. eCollection 2019. | |
| 27494527 |
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|
| Asprin / Clopidogrel, Atorvastatin / Simvastatin | Drug | Antiplatelet agents(Aspirin 75~150mg/day or Clopidogrel 75mg/day),statins(Atorvastatin 20mg/day or Simvastatin 20mg/day),risk factor lowering agents (antihypertension agents:Amlodipine 5mg/day or Benazepril 10mg/day or Valsartan 80mg/day or Nifedipine 30mg/day or Indapamide 2.5mg/day,antidiabetic agents: Metformin 0.5 tid or Glipizide 5mg tid or Acarbose 50mg tid )if necessary |
|
| 1 year after enrolled |
| Hemorrhagic Stroke | 1 year after enrolled |
| All-cause Death | 1 year after enrolled |
| Beijing |
| Beijing Municipality |
| 100853 |
| China |
| Beijing Daxing District Hospital | Beijing | Beijing Municipality | China |
| Beijing Ji Shui Tan Hospital,the 4Th Medical College of Peking University | Beijing | Beijing Municipality | China |
| Beijing Shijitan Hospital | Beijing | Beijing Municipality | China |
| Beijing Tiantan Hospital | Beijing | Beijing Municipality | China |
| China Rehabilition Research Center | Beijing | Beijing Municipality | China |
| General Hospital of Navy | Beijing | Beijing Municipality | China |
| Luhe Hospital of Tongzhou Distict Beijing | Beijing | Beijing Municipality | China |
| No 263 Hospital of Pla | Beijing | Beijing Municipality | China |
| No 309 Hospital of Pla | Beijing | Beijing Municipality | China |
| Peking University Third Hospital | Beijing | Beijing Municipality | China |
| Pinggu County Hospital Beijing | Beijing | Beijing Municipality | China |
| Xuanwu Hospital Capital Medical University | Beijing | Beijing Municipality | China |
| Daping Hospital | Chongqing | Chongqing Municipality | China |
| Southwest Hospital | Chongqing | Chongqing Municipality | China |
| Guangzhou First Municipal People'S Hospital | Guangzhou | Guangdong | China |
| The First Affiliated Hospital,Sun Yat-Sen Unversity | Guangzhou | Guangdong | China |
| The First Hospital of Hebei Medical University | Shijiazhuang | Hebei | China |
| The Second Hospital of Hebei Medical University | Shijiazhuang | Hebei | China |
| The Third Hospital of Hebei Medical University | Shijiazhuang | Hebei | China |
| Yutian County Hospital | Yutian | Hebei | China |
| Hebei North University | Zhangjiakou | Hebei | China |
| The First Hospital of Harbin Medical University | Harbin | Helongjiang | China |
| The Second Hospital of Harbin Medical University | Harbin | Helongjiang | China |
| Henan Provincial People'S Hospital | Zhengzhou | Henan | China |
| The Zhongnan Hospital of Wuhan University | Wuhan | Hubei | China |
| Xiangya Hospital of Centre-South University | Changsha | Hunan | China |
| Inner Mongolia Baotou City Central Hospital | Baotou | Inner Mongolia | China |
| The Appurtenant Hospital of Chifeng University | Chifeng | Inner Mongolia | China |
| Jiangsu Province Hospital | Nanjing | Jiangsu | China |
| Nanjing General Hospital of Nanjing Military Command | Nanjing | Jiangsu | China |
| The Affiliated Drumtower Hospital of Nanjing University Medical School | Nanjing | Jiangsu | China |
| Jilin University | Changchun | Jilin | China |
| The Third People'S Hospital of Dalian | Dalian | Liaoning | China |
| The First Affiliated Hospital of China Medical Sciences University | Shenyang | Liaoning | China |
| Qinghai Provincial People'S Hospital | Xining | Qinghai | China |
| Qilu Hospital of Shangdong University | Jinan | Shandong | China |
| The Second Hospitalof Shangdong University | Jinan | Shandong | China |
| Huashan Hospital Fudan University | Shanghai | Shanghai Municipality | China |
| Shanghai Changzheng Hospital | Shanghai | Shanghai Municipality | China |
| West China Center of Medical Sciences | Chengdu | Sichuan | China |
| The General Hospital Under Tianjin Medical Sciences University | Tianjin | Tianjin Municipality | China |
| Tianjin Third Central Hospital | Tianjin | Tianjin Municipality | China |
| First Affiliated Hospital of Xinjiang Medical University | Uramuqi | Xinjiang Uygur Autonomous Region | China |
| The First Affiliated Hospital of College of Medicine, Zhejiang University | Hangzhou | Zhejiang | China |
| Yao M, Ni J, Zhou L, Peng B, Zhu Y, Cui L; SMART investigators. Elevated Fasting Blood Glucose Is Predictive of Poor Outcome in Non-Diabetic Stroke Patients: A Sub-Group Analysis of SMART. PLoS One. 2016 Aug 5;11(8):e0160674. doi: 10.1371/journal.pone.0160674. eCollection 2016. |
| 26780948 | Derived | Ni J, Yao M, Zhou L, Zhu Y, Peng B, Cui L; SMART Investigators. A guideline-based program may improve the outcome of stroke among illiterate patients. Int J Stroke. 2016 Apr;11(3):332-7. doi: 10.1177/1747493015626151. Epub 2016 Jan 18. |
| 24385269 | Derived | Peng B, Ni J, Anderson CS, Zhu Y, Wang Y, Pu C, Wu J, Wang J, Zhou L, Yao M, He J, Shan G, Gao S, Xu W, Cui L; SMART Investigators. Implementation of a structured guideline-based program for the secondary prevention of ischemic stroke in China. Stroke. 2014 Feb;45(2):515-9. doi: 10.1161/STROKEAHA.113.001424. Epub 2014 Jan 2. |
| 21951412 | Derived | Peng B, Zhu Y, Cui L, Ni J, Xu W, Zhou L, Yao M, Chen L, Wang J, Wang Y, Pu C; SMART Study Group. Standard medical management in secondary prevention of ischemic stroke in China (SMART). Int J Stroke. 2011 Oct;6(5):461-5. doi: 10.1111/j.1747-4949.2011.00648.x. |
| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D001241 | Aspirin |
| D000077144 | Clopidogrel |
| D000069059 | Atorvastatin |
| D019821 | Simvastatin |
| ID | Term |
|---|---|
| D012459 | Salicylates |
| D062385 | Hydroxybenzoates |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D013988 | Ticlopidine |
| D058924 | Thienopyridines |
| D013876 | Thiophenes |
| D013457 | Sulfur Compounds |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D011758 | Pyrroles |
| D001393 | Azoles |
| D006538 | Heptanoic Acids |
| D005227 | Fatty Acids |
| D008055 | Lipids |
| D008148 | Lovastatin |
| D009281 | Naphthalenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D011083 | Polycyclic Compounds |
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