The Effect of Intravenous Lidocaine on Allodynia

The Effect of Intravenous Lidocaine on Allodynia (Carl Koller Grant)

The purpose of this study is to study if lidocaine, given intravenously, reduces pain.

Clinicians use lidocaine intravenously in a fashion that suggests that it might have analgesic effects. Therefore, we test the hypothesis that lidocaine reduces pain intensity in response to experimental pain.

Inclusion Criteria:

• Chronic Regional Pain Syndrome diagnostic criteria by the Work Safe BC. vi

Exclusion Criteria:

• History of Substance abuse
• Other Medications: CRPS patients are expected to be treated for chronic pain, whether the current treatment regimen interferes with sensory motor testing will be determined on a case by case basis.
• Coronary Artery Disease (CAD): unstable
• Congestive Heart Failure (CHF): unstable
• Heart Arrhythmia: symptomatic
• Chronic Obstructive Pulmonary Disease (COPD)
• Lidocaine Allergy
• Diagnostic and Statistical Manual of Mental Disorders (Rev IV): Axis I: Common Axis I disorders include depression, anxiety disorders, bipolar disorder, ADHD, and schizophrenia. Axis II: borderline personality disorder, schizotypal personality disorder, antisocial personality disorder, and mild mental retardation.
• Presence of Contraindications for MRI
• Presence of electronically, magnetically, and mechanically activated implants
• Electronically, magnetically, and mechanically activated implants
• Ferromagnetic or electronically operated active devices like automatic cardioverter defibrillators
• Cardiac pacemakers
• Metallic splinters in the eye
• Ferromagnetic haemostatic clips in the central nervous system (CNS)
• Claustrophobia
• Pregnancy