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| Name | Class |
|---|---|
| Karolinska Institutet | OTHER |
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The purpose of this study is to determine whether computerised cognitive rehabilitation training improves cognition in children who have had cerebral malaria.
Cerebral malaria affects several children in sub-Saharan Africa leaving some survivors with cognitive problems especially in attention and memory. There are currently no tested interventions for such deficits resulting from infectious diseases like malaria or other causes. Providing such interventions will go a long way in helping these children achieve their full potential.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cognitive rehabilitation training | Experimental | Children in this arm will the receive the intervention comprising of 16 cognitive rehabilitation training (CRT) exercises for 8 weeks. These exercises will train different cognitive skills including attention, visual spatial processing, logical skills and memory. |
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| Treatment as usual | No Intervention | Children in this group will not receive any intervention, they will undergo the usual post discharge treatment for brain injured children at Mulago Hospital (the study site). This is the treatment as usual (TAU) group. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cognitive rehabilitation training | Behavioral | A computerised cognitive training package where children will be required to complete several cognitive tasks. The aim is to strengthen the different cognitive processes during these tasks which in turn may lead to improve cognitive processes. Children will complete these tasks in 16 session for 8 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Improvement in attention scores | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Improvement in memory, reasoning, planning, behaviour and academic achievement | 6 months |
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CM group Inclusion Criteria:
CM group Exclusion Criteria:
Healthy control group Inclusion Criteria:
Healthy control group Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Charles Ibingira, MMED | Chairman, Makerere University Faculty of Medicine Research and Ethics Committee | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mulago hospital Acute Care Unit and the Cerebral Malaria Project | Kampala | Kampala | 7051 | Uganda |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16930255 | Background | Bangirana P, Idro R, John CC, Boivin MJ. Rehabilitation for cognitive impairments after cerebral malaria in African children: strategies and limitations. Trop Med Int Health. 2006 Sep;11(9):1341-9. doi: 10.1111/j.1365-3156.2006.01685.x. | |
| 17224457 | Background | Boivin MJ, Bangirana P, Byarugaba J, Opoka RO, Idro R, Jurek AM, John CC. Cognitive impairment after cerebral malaria in children: a prospective study. Pediatrics. 2007 Feb;119(2):e360-6. doi: 10.1542/peds.2006-2027. Epub 2007 Jan 15. |
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| ID | Term |
|---|---|
| D016779 | Malaria, Cerebral |
| ID | Term |
|---|---|
| D020808 | Central Nervous System Protozoal Infections |
| D020807 | Central Nervous System Parasitic Infections |
| D002494 | Central Nervous System Infections |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D000091942 | Cognitive Training |
| ID | Term |
|---|---|
| D000066530 | Neurological Rehabilitation |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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|
|
| D010272 | Parasitic Diseases |
| D008288 | Malaria |
| D011528 | Protozoan Infections |
| D000096724 | Mosquito-Borne Diseases |
| D000079426 | Vector Borne Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |