Due to poor accrual

To evaluate whether using the drug bortezomib at the start of remission will prevent relapse for a longer period of time.

Although advances in the treatment of multiple myeloma have led to improved remission rates, the risk for serious relapse is very high. The drug Bortezomib has been highly effective for treatment of the disease in an advanced stage such as post-transplant relapse. Due to the need of maintenance therapies, it is necessary to look to certain drugs that may prolong remission and increase the quality of life. Bortezomib, when taken at the beginning of remission, may prove to be a beneficial maintenance drug for the management of multiple myeloma.

Inclusion Criteria:

• Diagnosed with multiple myeloma currently or previously enrolled on UARK 98-026 and currently event-free at the time of the evaluation.
• Performance status of 0-2 based of Southwest Oncology Group (SWOG) criteria
• Previously documented platelet count > 75,000/ul within a 35 days prior to enrollment
• Previously documented peripheral absolute neutrophil count >1,000/ul within 35 days prior to enrollment.
• Adequate renal function
• Signed informed consent
• Female subject is post-menopausal or willing to use acceptable birth control
• Male subjects agree to use acceptable method of contraceptive

Exclusion Criteria:

• Hypersensitivity to Bortezomib, boron, or mannitol
• Female subject is pregnant or breastfeeding
• Experienced myocardial infraction within 6 months prior to enrollment
• Received other investigational new drugs within 14 days before enrollment
• Received any anti-myeloma therapy within 14 days
• Serious medical or psychiatric illness likely to interfere with participation in this clinical study
• Diagnosed or treated for another malignancy within 3 years of enrollment

there were no events reported in the five participants enrolled in the treatment arm or in the five participants enrolled in the observation arm of this study.

Early termination leading to small numbers of subjects analyzed