Copenhagen Obesity Risk Assessment Study

Copenhagen Obesity Risk Assessment Study - A Double Blind Randomized Dietary Intervention Study Examining the Effect of a High Intake of Trans Fatty Acids on Abdominal Obesity and Risk Markers of Type 2 Diabetes and Cardiovascular Disease.

The aim of the present study is to assess the effect of a high intake of industrially produced trans fatty acids for 16 weeks on abdominal obesity and risk markers of type 2 diabetes and heart disease in healthy, moderately overweight, postmenopausal women.

Inclusion Criteria:

• Age 45-70 years
• BMI 25-32
• Waist circumference > 80 cm
• Postmenopausal for at least 1 year

Exclusion Criteria:

• BP > 160/100 mmHg
• Fasted blood glucose > 7 mM
• Fasted LDL-cholesterol > 6 mM
• Fasted triglycerides > 3 mM
• Diabetes mellitus or other chronic diseases
• Current or previous cardiovascular disease
• Weight change > 3 kg within last 2 months
• Use of anti-hypertensive drugs
• Use of statins/fibrates
• Use of fish oil supplements
• Smoking
• Hard physical activity > 10 h/week