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Pomegranate has a long history of use in folk medicine. There is vast data on the health benefits of pomegranate fruit and juice. Multiple studies have established the strong antioxidative effects of pomegranate polyphenols (primarily the ellagitannin punicalagin) and their health effects. A vast number of animal and human clinical studies have provided evidence on effect of pomegranate products on reducing symptoms of common cold, reducing blood pressure, improving endothelial function, anti-tumor activity, and its anti-atherosclerotic activity. This study will evaluate the protective effect of a pomegranate concentrate (POMx) in decreasing the incidence and duration of the common cold among healthy adults.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Pomegranate concentrate (POMx) |
|
| 2 | Placebo Comparator | Fruit flavored juice low in antioxidants |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pomegranate Concentrate (POMx) | Dietary Supplement | 3.3 oz bottle containing antioxidants equivalent to 8 oz of pomegranate juice taken once daily for 7 days prior to infection and for 4 days after. |
| Measure | Description | Time Frame |
|---|---|---|
| The proportion of subjects who become infected in the active treatment group compared with the proportion of subjects who become infected in the placebo treatment group. | Days 1-5 |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of symptom scores in the treatment groups | Days 1-5 | |
| Determination of effects of treatment on immune function. | Days 1-5 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ronald B Turner, MD | University of Virginia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Accelovance Inc. | Huntsville | Alabama | 35802 | United States | ||
| Accelovance Inc |
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| ID | Term |
|---|---|
| D003139 | Common Cold |
| ID | Term |
|---|---|
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D010850 | Picornaviridae Infections |
| D012327 | RNA Virus Infections |
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| Placebo | Dietary Supplement | 3.3 oz bottle containing fruit flavored juice low in antioxidants taken once daily for 7 days prior to infection and for 4 days after. |
|
| Melbourne |
| Florida |
| 32935 |
| United States |
| University of Virginia School of Medicine | Charlottesville | Virginia | 22908 | United States |
| D014777 |
| Virus Diseases |
| D012140 | Respiratory Tract Diseases |