Effect of Insulin Glargine in Insulin Naïve Subjects With Type 2 Diabetes on Oral Hypoglycemic Agent(s)

Target Glycemic Control and the Incidence of Symptomatic Nocturnal Hypoglycemia in Insulin Naïve Subjects With Type 2 Diabetes on Oral Hypoglycemic Agent(s) and Treated With Insulin Glargine or NPH Human Insulin.

The primary objective of this study is to compare the percentage of subjects who reach the target HbA1c level (< or = 7.0% at endpoint) and do not experience symptomatic nocturnal hypoglycemia during treatment with insulin glargine or NPH human insulin.

Inclusion Criteria:

• Insulin naïve subjects with type 2 diabetes treated with oral hypoglycemic agents
• Body mass index between 26 and 40 kg/m2
• HbA1c between 7.5% and 10.0%
• Fasting plasma glucose >7.8 mmol/L and fasting C-peptide > or =0.25 nmol/L