The metabolism of PF-00868554 is primarily mediated by CYP3A, and it is anticipated that hepatic impairment will modify PF-00868554 plasma concentrations. Hence, it is important to determine the impact of varying degrees of hepatic impairment on the pharmacokinetics, safety and toleration of 200 mg PF-00868554 administered as a single-dose.

Inclusion Criteria:

• Male or females subjects of non-childbearing potential between the ages of 18 and 62 years of age, inclusive;
• Body Mass Index (BMI) of approximately 18 to 35 kg/m2; and a total body weigh >50 kg (110 lbs);

Exclusion Criteria:

• Subjects with Class C classification (Severe - Child-Pugh Scores greater than 10);
• Severe ascites and/or pleural effusion;
• Had a transplanted kidney, heart or liver;