A Study of the Effect of Nebivolol to Evaluate Its Vasodilatory Effects in Hypertensive Patients

Effect of Nebivolol on Forearm Vasodilation, Nitric Oxide Bioavailability, and Oxidative Stress in Patients With Stage 1/2 Hypertension

The study is designed to compare the effects of nebivolol (10, 20, 40mg/day) with another beta blocker, extended-release metoprolol, at a range of doses. Its purpose is to study the mechanism of action of nebivolol on forearm blood flow, nitric oxide availability and other biomarkers.

Inclusion Criteria:

• Male or female, ambulatory outpatients 18-79 years old at screening
• Minimum 2-year history of Stage I/II hypertension
• Qualifying blood pressure criteria for study entry and for randomization
• Willing to adhere to the dietary compliance and undergo protocol procedures
• Have a lifestyle that will permit him/her to attend all evaluations, including those conducted on consecutive days

Exclusion Criteria:

• Have any form of secondary hypertension
• Have clinically significant respiratory or cardiovascular disease
• Presence/history of coronary artery disease or peripheral vascular disease
• Have diabetes mellitus, Type I or II
• Have a history of hypersensitivity to nebivolol, metoprolol, or any beta-blocker