The objective of this study is to characterize the analgesic properties of single dose study of HKT-500 in subjects with pain caused by mild to moderate OA of the knee

A Randomized, Multicenter, Double-Blind, Single Dose Study of the Analgesic Properties of HKT-500 and Placebo in Subjects with Pain Caused by Mild to Moderate Osteoarthritis of the Knee

Inclusion Criteria:

• male or female 45 years of age or older
• with osteoarthritis of the knee

Exclusion Criteria:

• subject is a woman of childbearing potential
• who has a positive urine pregnancy test,
• is lactating, or who is not surgically sterile