Insulin Sensitivity and Substrate Metabolism Before and After Treatment in Patients With Growth Hormone Deficiency

Insulin Sensitivity and Substrate Metabolism Before and After Treatment in Patients With Growth Hormone Deficiency

The purpose of this study is to further characterize the treatment related changes in insulin sensitivity, substrate metabolism and intrahepatic-intramyocellular lipids in patients with growth hormone deficiency (GHD).

Inclusion Criteria:

• Written informed consent
• Must be of legal age and competent
• Age: >18 and <60 years old
• Presently diagnosed with growth hormone deficiency; if panhypopituitary, the patient must be sufficiently substituted in the other axis´s, for at least 3 months before inclusion in the study

Exclusion Criteria:

• Alcohol consumption >21 units per week
• Malignant disease
• Pregnancy
• Magnetic implants or material in the body
• Claustrophobia
• BMI >30
• Heart disease (NYHA >2)
• Uncontrolled hypertension
• Manifest diabetes mellitus
• Change in medication, with any influence on glucose metabolism, 2 months prior to and until the end of the trial.

Controls are matched on age, gender and BMI

Inclusion Criteria:

• Written informed consent
• Must be of legal age and competent

Exclusion Criteria:

• Alcohol consumption >21 units per week
• Malignant disease
• Pregnancy
• Magnetic implants or material in the body
• Claustrophobia
• Heart disease (NYHA >2)
• Uncontrolled hypertension
• Manifest diabetes mellitus
• Change in medication, with any influence on glucose metabolism, 2 months prior to and until the end of the trial