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| ID | Type | Description | Link |
|---|---|---|---|
| D5896C00732 |
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The purpose of this study is to compare the early onset of effect of Symbicort compared to Advair Diskus and Ventolin in adults with asthma
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | budesonide/formoterol |
|
| 2 | Active Comparator | fluticasone/salmeterol |
|
| 3 | Active Comparator | albuterol |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| budesonide/formoterol (Symbicort) | Drug |
|
| |
| fluticasone/salmeterol (Advair Diskus) |
| Measure | Description | Time Frame |
|---|---|---|
| FEV1 3 minutes post dose | 4 assessments across 4 visits whilst on treatment (visits may be between 3 and 14 days apart) |
| Measure | Description | Time Frame |
|---|---|---|
| 12 hour serial FEV1 | 4 assessments across 4 visits whilst on treatment (visits may be between 3 and 14 days apart) | |
| Patients perception of effect | 4 assessments across 4 visits whilst on treatment (visits may be between 3 and 14 days apart) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Catherine Bonuccelli | AstraZeneca | Study Director |
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| ID | Term |
|---|---|
| D001249 | Asthma |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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| ID | Term |
|---|---|
| D019819 | Budesonide |
| D000068759 | Formoterol Fumarate |
| D000069502 | Budesonide, Formoterol Fumarate Drug Combination |
| D000068298 | Fluticasone |
| D000068299 | Salmeterol Xinafoate |
| D000068297 | Fluticasone-Salmeterol Drug Combination |
| D000420 | Albuterol |
| ID | Term |
|---|---|
| D011282 | Pregnenediones |
| D011283 | Pregnenes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 |
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| Drug |
|
|
| albuterol (Ventolin) | Drug |
|
|
| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D000588 | Amines |
| D004338 | Drug Combinations |
| D004364 | Pharmaceutical Preparations |
| D000730 | Androstadienes |
| D000736 | Androstenes |
| D000731 | Androstanes |
| D010627 | Phenethylamines |
| D005021 | Ethylamines |