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| Name | Class |
|---|---|
| London School of Hygiene and Tropical Medicine | OTHER |
| International Atomic Energy Agency | OTHER_GOV |
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The malaria parasite Plasmodium falciparum remains at sub-patent level throughout the dry season in areas of seasonal malaria transmission. Targeting this parasite reservoir before the transmission season could be a good strategy for malaria control. We are conducting a randomized double blind placebo controlled mass drug administration trial in eight village to clear the dry season low level parasitaemia with an ultimate aim of controlling malaria in eastern Sudan.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | 1:Active comparator sulfadoxine-pyrimethamine plus artesunate |
|
| 2 | Placebo Comparator | 2:placebo comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sulfadoxine / Pyrimethamine (SP) plus artesunate (AS) | Drug | Standard three day regimen |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Parsitaemia detected during the transmission season among dry season PCR negative persons in the intervention and control villages | October to December 2006 |
| Measure | Description | Time Frame |
|---|---|---|
| 1. Malaria prevalence during the transmission season 2. Frequency of mutation in drug resistance genes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Badria B El Sayed, PhD,MSc,BSc | Tropical Medicine Research Institute | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tropical Medicine Research Institute | Khartoum | Khartoum State | 11111 | Sudan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34585740 | Derived | Shah MP, Hwang J, Choi L, Lindblade KA, Kachur SP, Desai M. Mass drug administration for malaria. Cochrane Database Syst Rev. 2021 Sep 29;9(9):CD008846. doi: 10.1002/14651858.CD008846.pub3. |
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| placebo tablet similar to active drug in shape and size |
| Drug |
Dosage similar to active drug(standard three days regimen) |
|
| ID | Term |
|---|---|
| D016778 | Malaria, Falciparum |
| ID | Term |
|---|---|
| D008288 | Malaria |
| D011528 | Protozoan Infections |
| D010272 | Parasitic Diseases |
| D007239 | Infections |
| D000096724 | Mosquito-Borne Diseases |
| D000079426 | Vector Borne Diseases |
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| ID | Term |
|---|---|
| D013413 | Sulfadoxine |
| D011739 | Pyrimethamine |
| ID | Term |
|---|---|
| D000096926 | Benzenesulfonamides |
| D013449 | Sulfonamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D013424 | Sulfanilamides |
| D000814 | Aniline Compounds |
| D000588 | Amines |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D013450 | Sulfones |
| D013457 | Sulfur Compounds |
| D011743 | Pyrimidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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