The primary purpose of the study is to determine the efficacy of oral dronabinol versus standard ondansetron antiemetic therapy in preventing delayed-onset chemotherapy-induced nausea and vomiting (CINV) or retching by measuring the incidence of total response of nausea and vomiting and/or retching following administration of moderate-to-high emetogenic chemotherapeutic agents.

Inclusion Criteria:

• Histological evidence of non-CNS malignancy (primary or metastatic disease) and lymphomas which are not involving the bone marrow.

• Undergoing single or multiple days of chemotherapy as long as Day 1 chemotherapy includes:

  1. a moderate-to-high emetogenic regimen, or
  2. oxaliplatin at doses employed for treatment of colon cancer, or
  3. the combination of AC [AdriamycinÒ (60 mg/m2) with cyclophosphamide (600 mg/m2)] as to be used for the chemotherapeutic drug regimen involving taxanes in the treatment of breast cancer.

Exclusion Criteria:

• Chemotherapy agents falling into the low (Level 1), moderate-to-low (Level 2), moderate (Level 3) unless used in combination with a Level 4 chemotherapy agent on Day 1 of the study.
• Chemotherapy agents falling into the high (Level 5) classification during study.
• Any combination of chemotherapy agents that does not fall into the moderate-to-high (Level 4) classification