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Cross-linking of the cornea increases the mechanical and biochemical stability of the stromal tissue. The purpose of this study is to assess the effectiveness of riboflavin-ultraviolet light induced cross-linking of corneal collagen in improving visual acuity and reducing progression of keratoconus in the Brazilian population.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| A | Experimental | The eye with the worst visual acuity receives the treatment. (the other eye serve as control). |
|
| B | No Intervention | The eye with the best visual acuity do not receive the treatment. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Corneal Collagen Crosslinking | Procedure | UV light and Riboflavin eyedrops every 5 minutes for 30 minutes. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Keratometry | 3 months | |
| BSCVA (Best spectacle corrected visual acuity) | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Endothelial cell count | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ricardo Lamy, MD | Contact | 55-21-2714-7646 | lamy@ufrj.br |
| Name | Affiliation | Role |
|---|---|---|
| Ricardo Lamy, MD | UFRJ | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clementino Fraga Filho University Hospital | Recruiting | Rio de Janeiro | Rio de Janeiro | 21941-913 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12719068 | Background | Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003 May;135(5):620-7. doi: 10.1016/s0002-9394(02)02220-1. | |
| 9533835 | Background | Spoerl E, Huhle M, Seiler T. Induction of cross-links in corneal tissue. Exp Eye Res. 1998 Jan;66(1):97-103. doi: 10.1006/exer.1997.0410. |
| Label | URL |
|---|---|
| Clementino Fraga Filho University Hospital | View source |
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| ID | Term |
|---|---|
| D007640 | Keratoconus |
| ID | Term |
|---|---|
| D003316 | Corneal Diseases |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D000094504 | Corneal Cross-Linking |
| ID | Term |
|---|---|
| D010778 | Photochemotherapy |
| D003131 | Combined Modality Therapy |
| D013812 | Therapeutics |
| D004358 | Drug Therapy |
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| 12091412 | Background | Kolozsvari L, Nogradi A, Hopp B, Bor Z. UV absorbance of the human cornea in the 240- to 400-nm range. Invest Ophthalmol Vis Sci. 2002 Jul;43(7):2165-8. |
| 11201780 | Background | Sekundo W, Stevens JD. Surgical treatment of keratoconus at the turn of the 20th century. J Refract Surg. 2001 Jan-Feb;17(1):69-73. doi: 10.3928/1081-597X-20010101-09. |
| 16765803 | Background | Caporossi A, Baiocchi S, Mazzotta C, Traversi C, Caporossi T. Parasurgical therapy for keratoconus by riboflavin-ultraviolet type A rays induced cross-linking of corneal collagen: preliminary refractive results in an Italian study. J Cataract Refract Surg. 2006 May;32(5):837-45. doi: 10.1016/j.jcrs.2006.01.091. |
| 17457183 | Background | Spoerl E, Mrochen M, Sliney D, Trokel S, Seiler T. Safety of UVA-riboflavin cross-linking of the cornea. Cornea. 2007 May;26(4):385-9. doi: 10.1097/ICO.0b013e3180334f78. |
| 14522301 | Background | Wollensak G, Spoerl E, Seiler T. Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking. J Cataract Refract Surg. 2003 Sep;29(9):1780-5. doi: 10.1016/s0886-3350(03)00407-3. |
| D010789 |
| Phototherapy |