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| Name | Class |
|---|---|
| The Danish Medical Research Council | OTHER |
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Aim: To investigate the effect of high intra- and postoperative oxygen concentration (80%, as opposed to normally 30%) on pulmonary gas exchange and other pulmonary complications after abdominal surgery.
Background: Previous studies have shown possible beneficial effects of high perioperative oxygen concentration on surgical wound infection and healing, but all pulmonary effects are not clarified. Change in perioperative PaO2/FiO2 and shunt-fraction, measured by a gas rebreathing technique, can describe pulmonary oxygenation. This could add knowledge to the pulmonary effects of high vs. normal oxygen concentration.
Primary hypothesis of study: Perioperative use of a 80% oxygen concentration reduces the PaO2/FiO2-index compared to 30% oxygen.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | Group 1 is given 30% oxygen during and 2 hours after surgery |
|
| 2 | Active Comparator | Group 2 is given 80% during and 2 hours after surgery. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oxygen | Drug | Inspiratory fraction during anaesthesia |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in PaO2/FiO2-index during general anaesthesia. | End of surgery. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in PaO2/FiO2-index during general anaesthesia and postoperative recovery. | 1½ hour after surgery. | |
| Atelectasis and Pneumonia | 14 days after surgery | |
| Arterial oxygen saturation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Christian S Meyhoff, MD | Dept. of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark | Study Director |
| Lars S Rasmussen, MD, PHD, DMSC | Dept. of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark | Study Chair |
| Steen Henneberg, MD,DMSC | Dept.of Anaesthesia, The Juliane Marie Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark | Study Director |
| Anne Kathrine Stæhr | Detp. of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark | Principal Investigator |
| Poul L Christensen, MD | Dept. of Anaesthesia and Intensive Care, Copenhagen University Hospital, Bispebjerg Hospital, Copenhagen, Denmark | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22840231 | Derived | Staehr AK, Meyhoff CS, Henneberg SW, Christensen PL, Rasmussen LS. Influence of perioperative oxygen fraction on pulmonary function after abdominal surgery: a randomized controlled trial. BMC Res Notes. 2012 Jul 28;5:383. doi: 10.1186/1756-0500-5-383. |
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| ID | Term |
|---|---|
| D010100 | Oxygen |
| ID | Term |
|---|---|
| D018011 | Chalcogens |
| D004602 | Elements |
| D007287 | Inorganic Chemicals |
| D005740 | Gases |
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| 2 hours and 3 days after surgery. |
| Change in functional residual capacity (FRC) | 2 hours after surgery. |
| Change in effective pulmonary bloodflow | 2 hours after surgery. |