Effects Of Food And Dose Regimen On The Antiviral Effects Of Maraviroc (UK-427,857) In Patients With Human Immunodeficiency Virus

An Investigation Into The Effects Of Food And Dose Regimen On Viral Load Response In HIV Infected Patients On Short-Term Monotherapy With UK-427,857 (Maraviroc)

To investigate the effects of food and dose regimen on the antiviral effects of Maraviroc (UK-427,857) in patients with human immunodeficiency virus (HIV)

Inclusion Criteria:

• Asymptomatic HIV-1 infected male and female patients
• Weight between 50 and 100kg and within the permitted range for their height
• Patients with virus that targets CCR5 receptor

Exclusion Criteria:

• Patients with a CD4 count <250 cells/mm3 or HIV viral load <5000 copies/mL
• Patients whose HIV infection has been diagnosed less than 3 months prior to screening, or for who there is evidence of recent seroconversion
• Patients with acquired immunodeficiency syndrome (AIDS) or a previous AIDS diagnosis
• Patients who are taking or have taken antiretroviral drugs in the eight weeks prior to the study screening visit