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| Name | Class |
|---|---|
| Fars Heart Foundation | UNKNOWN |
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The purpose of this study is whether Acetazolamide is effective in prevention of contrast nephropathy
Contrast induced nephropathy is one of common causes of acute renal failure many preventive protocol existed . 240 patient that underwent coronary angiography randomly divided in three groups.Group 1,2,3 will receive Bicarbonate ,Acetazolamide+Normal salin and Normal salin respectively.We compare prevalence of contrast nephropathy in each group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | 150 meq/l NaHco3 3cc/kg/hr one Hour before and 1cc/kg/hr 6 hour after angiography |
|
| 2 | Active Comparator | Acetazolamide 250 mg + 1cc/kg/hr normal salin 6 hour before and after angiography |
|
| 3 | Active Comparator | normal salin 1cc/kg/hr before and after angiography |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| sodium bicarbonate | Drug | 150 meq/l Sodium bicarbonate 3cc/kg/hr before and 1cc/kg/hr after angiography |
|
| Measure | Description | Time Frame |
|---|---|---|
| Increased base line creatinine at least 25% | 24 hr later |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Maryam Pakfetrat, MD | Shiraz nephro-urology research center | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fars Heart Foundation , Kowsar hospital | Shiraz | Iran |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16391986 | Result | Assadi F. Acetazolamide for prevention of contrast-induced nephropathy: a new use for an old drug. Pediatr Cardiol. 2006 Mar-Apr;27(2):238-42. doi: 10.1007/s00246-005-1132-z. |
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| ID | Term |
|---|---|
| D017693 | Sodium Bicarbonate |
| D000086 | Acetazolamide |
| ID | Term |
|---|---|
| D001639 | Bicarbonates |
| D002254 | Carbonates |
| D002255 | Carbonic Acid |
| D017554 | Carbon Compounds, Inorganic |
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| Acetazolamide | Drug | Acetazolamide 250 mg+ 1 cc/kg/hr normal salin before and after angiography |
|
|
| normal salin | Drug | 1 cc/kg/hr 6 hour before and after angiography |
|
|
| D007287 |
| Inorganic Chemicals |
| D017670 | Sodium Compounds |
| D013830 | Thiadiazoles |
| D013844 | Thiazoles |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |