Characterization of Interferon Beta -1b-Induced Tolerizing Effect in Dendritic Cells

Characterization of Interferon Beta -1b-Induced Tolerizing Effect in Dendritic Cells

Determine the in-vivo mechanism of action of INF-B-1b as it's mechanisms of action are not completely understood. We propose that high dose exogenous recombinant IFN-B-1b induces tolerizing effect on DC-dependent T-cell differentiation in patients with MS by inducing the expression of SOCS3 in DCs.

Inclusion Criteria:

• Confirmed diagnosis of MS
• Age 18-60 years, inclusive
• Expanded disability status of 0-6.5
• Give written informed consent prior to any testing under this protocol