Efficacy of Somatropin in Adult Patients With Isolated Growth Hormone Deficiency

Prospective, Randomized, Double Blind Placebo-Controlled Trial On The Efficacy Of Growth Hormone Replacement Therapy In Adult Patients With Isolated Growth Hormone Deficiency (PRO ISO-GHD Study)

The study will investigate the effect on growth hormone replacement in patients with isolated growth hormone deficiency on body composition, especially visceral fat mass.

The study was terminated on 15-Dec-2008 due to poor recruitment. Although 9 Patients were enrolled, no patient was randomized nor treated with somatropin. No safety reasons contributed to the termination.

Inclusion Criteria:

• Males and females between 18 and 65 years of age
• Isolated growth hormone deficiency

Exclusion Criteria:

• Isolated growth hormone deficiency by childhood onset
• Diabetes mellitus type 1 or 2