This study was designed to evaluate the symptomatic effects or potential disease progression slowing down effect of a kind of Traditional Chinese Medicinal Mixture in Parkinson's disease (PD) patients. The treatment phase includes 12 months period of Traditional Chinese Medicinal Mixture per day or placebo and 1 month wash-out period without herbal medicine and placebo.

The design of the study was a prospective, randomized, multicenter, double-blind placebo-controlled protocol. The intervention includes Traditional Chinese Medicinal Mixture tid or matched placebo.

Participating study centers include Neurological University Outpatient Clinics and Neurological Departments of Community-based Hospitals experienced with PD patients.

The primary outcome measure was the combined Unified Parkinson's Disease Rating Scale (UPDRS).

The hypothesis of this study was that Traditional Chinese Medicinal Mixture improves the overall wellbeing of PD patients and thus may leads to an improvement of parkinsonian symptoms in PD patients.

Inclusion Criteria:

• Parkinson's disease according to the UK Brain Bank criteria
• Hoehn & Yahr stadium Ⅰ～Ⅲ
• Age over 50 years
• Taking only levodopa and/or dopamine agonists when recruiting
• Consistent with the liver kidney deficiency type by Traditional Chinese Medicine (TCM) standard
• Patients voluntarily take part in this study and signed the informed consent

Exclusion Criteria:

• Modified Hoehn-Yahr scale are higher than 4
• Had other serious illness such as liver/kidney failure, serious infection etc
• Allergic to the study drug
• Had been participated in other clinical trials during the last 3 months prior to study inclusion.
• Taking Coenzyme Q10, MAO-B inhibitors, or vitamin E, all of which might improve the symptom or slowdown the progression of PD.
• Taking herbal medicine that can nourish the liver and kidney by TCM standard.
• Had serious mental disorder and could not describe his/her symptom.