Chronic Posterior Laryngitis With Suspected Laryngopharyngeal Reflux

A Multicenter, Double -Blind, Placebo-controlled Study to Evaluate the Effects of Esomeprazole 40mg Bid on the Signs and Symptoms of Chronic Posterior Laryngitis With Suspected Laryngopharyngeal Reflux

This study looks at how effective acid suppression therapy is on symptoms associated with chronic posterior laryngitis (CPL) in patients with documented pharyngeal acid reflux.

Inclusion Criteria:

• One or more of the following symptoms present for at least 3 consecutive months: throat clearing, cough, globus, sore throat, or hoarseness.
• Patients must complete a run-in diary card, and this will be looked at to ensure met the inclusion criteria.
• Must have a total score of 5 or more on the Chronic Posterior Laryngitis Index (CPLI) grading system.

Exclusion Criteria:

• A number of diseases / conditions would preclude a patient from taking part in the study, as listed in the protocol.
• If the patient is on certain medications this will also preclude them from taking part.