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The purpose of this study is to prospectivly analyze the correlation of triglyceride tolerance and glucose tolerance with cardiovascular morbidity and mortality in patients with stable coronary artery disease within 18 months and to determine, whether measurement of triglyceride tolerance can discriminate patients at risk for cardiovascular events.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | > 500 consecutive patients with coronary artery disease fulfilling eligibility criteria. |
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| Measure | Description | Time Frame |
|---|---|---|
| Parameters of triglyceride tolerance and glucose tolerance in correlation to cardiovascular events, cardiovascular mortality, total mortality. | 48 months after inclusion. |
| Measure | Description | Time Frame |
|---|---|---|
| Waist-to-Hip ratio, nutrition protocol, physical activity, non-invasive endothelial function, body fat composition, other biomarkers of lipid and glucose metabolism. | Directly after inclusion. |
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Inclusion Criteria:
Exclusion Criteria:
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> 500 consecutive patients with stable coronary artery disease being treated in the cardiology department of the university hospital.
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| Name | Affiliation | Role |
|---|---|---|
| Ulrich Laufs, MD | University Hospital, Saarland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Homburg / Saar - Cardiology Department | Homburg | Saarland | 66421 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25012240 | Result | Werner C, Filmer A, Fritsch M, Groenewold S, Graber S, Bohm M, Laufs U. Risk prediction with triglycerides in patients with stable coronary disease on statin treatment. Clin Res Cardiol. 2014 Dec;103(12):984-97. doi: 10.1007/s00392-014-0740-0. Epub 2014 Jul 11. | |
| 32473635 | Derived | Katzmann JL, Werner CM, Stojakovic T, Marz W, Scharnagl H, Laufs U. Apolipoprotein CIII predicts cardiovascular events in patients with coronary artery disease: a prospective observational study. Lipids Health Dis. 2020 May 30;19(1):116. doi: 10.1186/s12944-020-01293-9. |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| D003920 | Diabetes Mellitus |
| D024821 | Metabolic Syndrome |
| D006949 | Hyperlipidemias |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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Serum
| 25408147 | Derived | Hoffmann MM, Werner C, Bohm M, Laufs U, Winkler K. Association of secreted frizzled-related protein 4 (SFRP4) with type 2 diabetes in patients with stable coronary artery disease. Cardiovasc Diabetol. 2014 Nov 19;13:155. doi: 10.1186/s12933-014-0155-2. |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |