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The investigators hypothesized that complementary intracoronary streptokinase administration to primary percutaneous intervention in patients with acute myocardial infarction may provide limitation infarct size and improvement in left ventricular volumes and function in acute and late phases (6 months).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Following standard primary percutaneous coronary intervention for ST elevation acute myocardial infarction 250.000 U intracoronary Streptokinase will be given |
|
| 2 | Active Comparator | Standard percutaneous coronary intervention for ST elevation myocardial infarction will be performed |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Streptokinase | Drug | intracoronary infusion, 250.000 Units |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Left ventricular infarct size by SPECT | at long term (5-6 months) | |
| Left ventricular diastolic volume | at long term (5-6 months) | |
| Left ventricular systolic volume | at long term (5-6 months) | |
| Left ventricular ejection fraction | at long term (5-6 months) |
| Measure | Description | Time Frame |
|---|---|---|
| Temporal changes (from baseline to 5 months follow-up) in microvascular perfusion indices (index of microvascular resistance, coronary flow reserve) and in infarct size have been interrogated in only control group. | early phase (at discharge) and late phase (5-6 months) | |
| Reinfarction |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Murat Sezer, Assoc. Prof. | Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology | Principal Investigator |
| Sabahattin Umman, Prof. | Istanbul University,Istanbul Faculty of Medicine, Department of Cardiology | Study Director |
| Arif O Cimen, M.D. | Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology | Study Chair |
| Emre K Aslanger, M.D. | Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology | Study Chair |
| Berrin Umman, Prof. | Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology | Study Chair |
| Zehra Bugra, Prof. | Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology | Study Chair |
| Isik Adalet, Prof. | Istanbul University, Istanbul Faculty of Medicine, Department of Nuclear Medicine | Study Chair |
| Cuneyt Turkmen, Assoc. Prof. | Istanbul University, Istanbul Faculty of Medicine, Department of Nuclear Medicine | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology | Istanbul | 34290 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17476008 | Background | Sezer M, Oflaz H, Goren T, Okcular I, Umman B, Nisanci Y, Bilge AK, Sanli Y, Meric M, Umman S. Intracoronary streptokinase after primary percutaneous coronary intervention. N Engl J Med. 2007 May 3;356(18):1823-34. doi: 10.1056/NEJMoa054374. |
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| primary percutaneous coronary intervention | Procedure | balloon catheter, stent |
|
| from recruitment until the last follow-up at 5-6 months |
| Major bleeding | from recruitment to discharge |
| ID | Term |
|---|---|
| D054058 | Acute Coronary Syndrome |
| D015427 | Reperfusion Injury |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D013300 | Streptokinase |
| ID | Term |
|---|---|
| D010450 | Endopeptidases |
| D010447 | Peptide Hydrolases |
| D006867 | Hydrolases |
| D004798 | Enzymes |
| D045762 | Enzymes and Coenzymes |
| D010960 | Plasminogen Activators |
| D001779 | Blood Coagulation Factors |
| D001798 | Blood Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
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