AED/Statin Interaction Study

An Open-label, Two-cohort Study to Assess the Effect of Lamotrigine and Phenytoin on the Pharmacokinetics of Atorvastatin in Healthy Subjects

This study will evaluate the amount of the cholesterol-lowering drug atorvastatin available in the bloodstream, when taken together with the anti-seizure drugs lamotrigine or phenytoin.

Key Inclusion Criteria:

• Body weight >50kg (men) or >45kg (women) and BMI within the range 19-32 kg/m2 inclusive.
• No clinically significant abnormality on clinical examination

Key Exclusion Criteria:

• History or evidence of drug or alcohol abuse or active tobacco use.
• Women of childbearing potential
• Use of prescribed or non-prescribed medications during and within 14 days of starting study medication.