Study was terminated for futility following the planned interim analysis.

This is a trial to investigate the effectiveness and safety of [S,S]-Reboxetine in relieving chronic peripheral pain suffered by patients with diabetes. Some evidence for the effectiveness of [S,S]- Reboxetine in relieving chronic pain has been seen in 3 completed trials.

Inclusion Criteria:

• Male or female of any race at least 18 years of age
• Diagnosis of painful, distal, symmetrical, sensory-motor polyneuropathy, which is due to diabetes, for at least 1 year
• Patients at Visit 1 must have a score ≥40 mm on the Pain Visual Analogue Scale

Exclusion Criteria:

• Patients with significant hepatic impairment
• Neurological disorders unrelated to diabetic neuropathy that may confuse the assessment of neuropathic pain
• Any pain or other condition that may confound assessment or self-evaluation of the pain due to diabetic neuropathy
• Amputations other than toes
• A current or recent diagnosis (past 6 months) or episode of major depressive disorder and/or uncontrolled depression
• History of transient ischemic attack or stroke
• Myocardial infarction or unstable angina within the past three months