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| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
| European Foundation for the Study of Diabetes | OTHER |
| Novo Nordisk A/S | INDUSTRY |
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To evaluate the impact of laparoscopic adjustable gastric banding (LAGB) on beta-cell function, insulin sensitivity, incretin function, postprandial secretion of incretin hormones (glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)) in morbidly obese patients and to describe the pathophysiological mechanisms involved in the amelioration of glucose homeostasis during long-term weight loss.
Morbid obesity represents a serious health issue in Western countries, with a rising incidence and a strong association with increased mortality and serious co-morbidities, such as diabetes. Surgical interventions, such as laparoscopic gastric banding have been developed with the aim of providing a laparoscopic placed device that is safe and effective in generating substantial weight loss. By investigation of the incretin effect, the secretion of GIP and GLP-1, the insulin response and sensitivity and the beta-cell responsiveness to glucose in 10 obese patients without type 2 diabetes before and after laparoscopic gastric banding the aim of this project is describe the pathophysiological mechanisms involved in the amelioration of glucose homeostasis during long-term weight loss.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| A | Obese patients without diabetes with a Body Mass Index > 37 kg/m2 |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oral glucose tolerance test (OGTT), isoglycemic iv. clamp, liquid meal test, gastric emptying rate | Other | OGTT: The test is performed with 50 g of glucose deluded in 300 ml water Isoglycemic iv. clamp: Iv. glucose infusion mimicking the glucose response curves from the OGTT Liquid Meal test: The test is performed with 100g of formula milk deluded in 300 ml. water Gastric Emptying Rate: Paracetamol absorption test. |
| Measure | Description | Time Frame |
|---|---|---|
| Incretin effect before and one year after gastric banding in obese patients without diabetes | One year |
| Measure | Description | Time Frame |
|---|---|---|
| GLP-1 and GIP response curves | One year |
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Exclusion Criteria:
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The cases and controls are recruited from The Bariatric Clinic at Glostrup Hospital
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| Name | Affiliation | Role |
|---|---|---|
| Katrine Bagge Hansen, MD | Glostrup University Hospital, Copenhagen | Principal Investigator |
| Filip K Knop, MD, PhD | Gentofte Hospital | Study Director |
| Steen Larsen, MD, DMSc | Glostrup University Hospital, Copenhagen | Study Director |
| Jens Juul Holst, MD,DMSc | University of Copenhagen | Study Director |
| Viggo Kristensen, MD | Glostrup University Hospital, Copenhagen | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Glostrup Hospital | Glostrup Municipality | 2600 | Denmark |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D005951 | Glucose Tolerance Test |
| ID | Term |
|---|---|
| D001774 | Blood Chemical Analysis |
| D019963 | Clinical Chemistry Tests |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
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p-glucose, p-glucagon, p-GLP1, p-GIP, p-cpeptid, p-insulin, p-paracetamol, buffy coat, urine, whole blood sampels
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| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D003933 | Diagnosis |
| D003940 | Diagnostic Techniques, Endocrine |
| D008919 | Investigative Techniques |