Study of Eye Bank Pre-cut Donor Grafts for Endothelial Keratoplasty

A Prospective, Randomized, Single Center Study Evaluating Use of Surgeon- and Eye Bank-prepared Donor Tissue for Descemet's Stripping and Endothelial Keratoplasty, a Type of Cornea Transplant

Descemet's stripping with endothelial keratoplasty (DSEK) is a cornea-sparing transplant technique that replaces only the diseased endothelial cell layer of the patient's cornea. The DSEK technique requires lamellar dissection of the donor tissue prior to implantation in the patient's eye. The surgeon usually dissects the donor cornea with a microkeratome at the time of surgery. Recently some eye banks have begun to pre-cut the donor graft as an added service. The purpose of this study was to compare outcomes with eye bank pre-cut and surgeon-dissected donor grafts for DSEK.

Inclusion Criteria:

• candidate for Descemet's stripping with endothelial keratoplasty
• at least 21 years old
• willing and able to return for scheduled follow-up visits
• reads and signs Informed Consent document

Exclusion Criteria:

• visual acuity of less than 20/400 in fellow eye
• known sensitivity to planned study concomitant medications