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| ID | Type | Description | Link |
|---|---|---|---|
| 04/Q1104/26 |
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| Name | Class |
|---|---|
| North of England Medical & Hyperbaric Services | UNKNOWN |
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The purpose of this study was to determine if treating patients who have coronary heart disease with hyperbaric oxygen (HBO) prior to coronary artery bypass graft (CABG) surgery reduces injury to the heart and vascular system during and after surgery. Furthermore, this study also aims to identify some of the post CABG clinical effects of HBO treatment prior to CABG.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| A | No Intervention | Patients in this arm were not treated with HBO prior to CABG | |
| B | Experimental | Patients in this arm were treated with HBO prior to CABG |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hyperbaric Oxygen | Drug | 100% Oxygen at 2.4 ATA for 30 minutes followed by 5 minutes break followed by 100% Oxygen at 2.4 ATA for another 30 minutes. This intervention was given about 4 to 5 hours prior to CABG |
| Measure | Description | Time Frame |
|---|---|---|
| Myocardial Hsp72 protein | Intra-operative (During CABG) | |
| Myocardial eNOS protein | Intra-Operative (During CABG) | |
| Serum Troponin-T | Peri-operative | |
| Serum soluble ICAM-1 | Peri-operative | |
| Serum soluble PSGL-1 | Peri-operative | |
| Serum soluble P-Selectin | Peri-operative | |
| Serum soluble E-Selectin | Peri-operative |
| Measure | Description | Time Frame |
|---|---|---|
| All cardiovascular haemodynamic parameters as measured by a pulmonary artery catheter | Peri-operative | |
| Duration of mechanical ventilation | Post Operative | |
| Duration of endotracheal intubation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jeysen Z Yogaratnam, MB.BCh, BAO, MRCS | Hull & East Yorkshire NHS Trust (Castle Hill Hospital), United Kingdom | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hull & East Yorkshire NHS Trust (Castle Hill Hospital) | Hull | East Riding Of Yorkshire | HU16 5JQ | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17996900 | Background | Yogaratnam JZ, Laden G, Guvendik L, Cowen M, Cale A, Griffin S. Pharmacological preconditioning with hyperbaric oxygen: can this therapy attenuate myocardial ischemic reperfusion injury and induce myocardial protection via nitric oxide? J Surg Res. 2008 Sep;149(1):155-64. doi: 10.1016/j.jss.2007.09.003. Epub 2007 Oct 11. | |
| 17526467 |
| Label | URL |
|---|---|
| publication link - Abstract | View source |
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| ID | Term |
|---|---|
| D015428 | Myocardial Reperfusion Injury |
| ID | Term |
|---|---|
| D009202 | Cardiomyopathies |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D017202 | Myocardial Ischemia |
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| ID | Term |
|---|---|
| D006931 | Hyperbaric Oxygenation |
| ID | Term |
|---|---|
| D010102 | Oxygen Inhalation Therapy |
| D012138 | Respiratory Therapy |
| D013812 | Therapeutics |
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|
| post operative |
| Length of stay in ICU | Post-operative |
| Blood loss | Post operative |
| Inotrope usage | Post operative |
| Atrial Fibrillation | Post operative |
| Low cardiac output status | Post operative |
| Pulmonary complications | Post operative |
| Renal Complications | Post operative |
| Cerebrovascular complications | Post operative |
| Gastrointestinal complications | Post operative |
| Wound complications | Post operative |
| Cost of ICU stay | Post operative |
| Yogaratnam JZ, Laden G, Guvendik L, Cowen M, Cale A, Griffin S. Can hyperbaric oxygen be used as adjunctive heart failure therapy through the induction of endogenous heat shock proteins? Adv Ther. 2007 Jan-Feb;24(1):106-18. doi: 10.1007/BF02849998. |
| 16945821 | Background | Yogaratnam JZ, Laden G, Madden LA, Seymour AM, Guvendik L, Cowen M, Greenman J, Cale A, Griffin S. Hyperbaric oxygen: a new drug in myocardial revascularization and protection? Cardiovasc Revasc Med. 2006 Jul-Sep;7(3):146-54. doi: 10.1016/j.carrev.2006.04.006. |
| 21721351 | Background | Jeysen ZY, Gerard L, Levant G, Cowen M, Cale A, Griffin S. Research report: the effects of hyperbaric oxygen preconditioning on myocardial biomarkers of cardioprotection in patients having coronary artery bypass graft surgery. Undersea Hyperb Med. 2011 May-Jun;38(3):175-85. |
| 20129356 | Derived | Yogaratnam JZ, Laden G, Guvendik L, Cowen M, Cale A, Griffin S. Hyperbaric oxygen preconditioning improves myocardial function, reduces length of intensive care stay, and limits complications post coronary artery bypass graft surgery. Cardiovasc Revasc Med. 2010 Jan-Mar;11(1):8-19. doi: 10.1016/j.carrev.2009.03.004. |
| D014652 |
| Vascular Diseases |
| D015427 | Reperfusion Injury |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |