The Protective Effects Of Treatment With Hyperbaric Oxygen Prior To Bypass Heart Surgery

The Effects of Hyperbaric Oxygen Preconditioning On Cardiovascular Protection & Ischemic Reperfusion Injury

The purpose of this study was to determine if treating patients who have coronary heart disease with hyperbaric oxygen (HBO) prior to coronary artery bypass graft (CABG) surgery reduces injury to the heart and vascular system during and after surgery. Furthermore, this study also aims to identify some of the post CABG clinical effects of HBO treatment prior to CABG.

Inclusion Criteria:

• Patients undergoing elective first time CABG
• Patients with at least 1 vessel coronary artery disease undergoing on- pump CABG

Exclusion Criteria:

• Age ≤ 20 years or ≥ 85 years
• Ejection fraction < 30%
• Unstable angina
• Recent myocardial infarction (< 1 month)
• Any additional cardiac disease (e.g. arrythmia, aneurysm, valvular/septal disease, dissection or elevated pulmonary artery pressure)
• Any end stage organ failure (e.g. renal and respiratory failure)
• History of chronic obstructive pulmonary disease (COPD)
• Pneumothorax
• Pulmonary bullae
• Convulsions
• Current history of malignancy
• Severe myopia or intraocular lens
• Patients on K+(ATP) Channel Openers e.g. Nicorandil, Oral Hypoglycemics, Opioid Analgesics, Catecholamines.