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Patients undergoing cardiac surgery could develop postoperative acute renal failure requiring renal replacement therapy.
Fenoldopam, already used for patients with hypertensive emergencies, could improve renal function in critically ill patients with or at risk for acute renal failure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fenoldopam | Experimental | Fenoldopam 0.1 ug/kg/min (from 0.025 to 0.3 ug/kg/min) for up to 4 days |
|
| Placebo | Placebo Comparator | Placebo (normosaline), continuous perfusion |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fenoldopam | Drug | fenoldopam 0.1 ug/kg/min (from 0.025 to 0.3 ug/kg/min)for up to 4 days |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients requiring Renal Replacement Therapy | participants will be followed for the duration of intensive care unit stay, an expected average of one week |
| Measure | Description | Time Frame |
|---|---|---|
| Number of dead patients. | Participants will be followed for 1 year. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| A.O. Universitario Policlinico S.Orsola Malpighi | Bologna | Italy | ||||
| Pres.Ospedal. Spedali Civili Brescia - Brescia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39607014 | Derived | Esezobor CI, Bhatt GC, Effa EE, Hodson EM. Fenoldopam for preventing and treating acute kidney injury. Cochrane Database Syst Rev. 2024 Nov 28;11(11):CD012905. doi: 10.1002/14651858.CD012905.pub2. | |
| 25265449 | Derived | Bove T, Zangrillo A, Guarracino F, Alvaro G, Persi B, Maglioni E, Galdieri N, Comis M, Caramelli F, Pasero DC, Pala G, Renzini M, Conte M, Paternoster G, Martinez B, Pinelli F, Frontini M, Zucchetti MC, Pappalardo F, Amantea B, Camata A, Pisano A, Verdecchia C, Dal Checco E, Cariello C, Faita L, Baldassarri R, Scandroglio AM, Saleh O, Lembo R, Calabro MG, Bellomo R, Landoni G. Effect of fenoldopam on use of renal replacement therapy among patients with acute kidney injury after cardiac surgery: a randomized clinical trial. JAMA. 2014 Dec 3;312(21):2244-53. doi: 10.1001/jama.2014.13573. |
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| ID | Term |
|---|---|
| D018818 | Fenoldopam |
| ID | Term |
|---|---|
| D001552 | Benzazepines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
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| placebo | Drug | placebo |
|
| Brescia |
| Italy |
| Azienda Ospedaliera Universitaria "Mater Domini" Catanzaro | Catanzaro | Italy |
| Azienda Ospedaliero Universitaria Careggi - Firenze | Florence | Italy |
| Città di Lecce Hospital GVM Care and Research Lecce | Lecce | Italy |
| Villa Maria Cecilia di Cotignola | Lugo Di Ravenna | Italy |
| Azienda Ospedaliera Papardo - Messina | Messina | Italy |
| Università Vita-Salute San Raffaele, Milano, Italia e Istituto Scientifico San Raffaele, Milano, Italia | Milan | 20132 | Italy |
| Azienda Ospedaliera Vincenzo Monaldi - Napoli | Naples | Italy |
| Azienda Ospedaliera di Padova | Padova | Italy |
| Azienda Ospedaliera di Perugia - Policlinico Monteluce(Osp. S.Maria della Misericordia) | Perugia | Italy |
| Azienda Ospedaliero Universitaria Pisana - Pisa | Pisa | Italy |
| A.O.Universitario Policlinico Tor Vergata - Roma | Roma | Italy |
| Ospedale Civile SS Annunziata di Sassari | Sassari | Italy |
| Azienda Ospedaliera Universitaria Senese (Policlinico S.Maria alle Scotte) | Siena | Italy |
| Azienda Ospedaliera San Giovanni Battista Molinette di Torino | Torino | Italy |
| Ospedale Mauriziano Umberto I di Torino | Torino | Italy |
| Ospedale S.Maria di Ca' Foncello | Treviso | Italy |
| Azienda Ospedaliera Universitaria Santa Maria della Misericordia | Udine | Italy |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |