Safety and Tolerability of Single and Multiple Doses of VAK694 in Healthy and Atopic Subjects

A Phase I Study to Assess the Safety, Tolerability, Pharmacokinetic Profile and Pharmacodynamic Effect of Single and Multiple Doses of VAK694 in Healthy and Atopic Subjects

This study will evaluate the safety and tolerability of single and multiple doses of VAK694 in healthy volunteers and otherwise healthy volunteers with a history of allergies.

Inclusion Criteria:

• History of allergic rhinitis (Part 2 only)

Exclusion Criteria:

• Very low or high body weight
• Heavy or recent smoker
• Exposure to human monoclonal antibodies

Other protocol-defined inclusion/exclusion criteria may apply.