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We evaluated the effects of giving a single dose of steroid before thyroid surgery in a single institutional, double-blinded, randomized controlled trial. Postoperative nausea, pain, and vocal function were significantly improved after steroid administration compared to controls.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| A, 1 | Placebo Comparator | Placebo 45 minutes prior to surgery |
|
| A, 2 | Active Comparator | 8 mg Dexamethasone 45 minutes prior to surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexamethason Helvepharm ® | Drug | 8 mg Dexamethason i.v. 45 minutes prior to surgery |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Nausea | 0-72 hours postoperative |
| Measure | Description | Time Frame |
|---|---|---|
| Pain, vocal function | 0-72 hours postoperative |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stephan A. Vorburger, MD | Dept of visceral- and transplant surgery, University Hospital Bern | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of visceral- and transplant surgery | Bern | 3010 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19092351 | Derived | Worni M, Schudel HH, Seifert E, Inglin R, Hagemann M, Vorburger SA, Candinas D. Randomized controlled trial on single dose steroid before thyroidectomy for benign disease to improve postoperative nausea, pain, and vocal function. Ann Surg. 2008 Dec;248(6):1060-6. doi: 10.1097/SLA.0b013e31818c709a. |
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| ID | Term |
|---|---|
| D009325 | Nausea |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Placebo |
| Drug |
100 ml sodium chloride i.v. 45 minutes prior to surgery |
|