Insulin Secretory Capacity in Insulin-independent Pancreas-Kidney Recipients Compared to Controls

Insulin Secretory Capacity in Insulin-independent Pancreas-Kidney Recipients Compared to Non-Diabetic Kidney Recipients, Insulin Independent Recipients of Beta-cell Grafts and Healthy Controls.

The purpose of this study is to compare functional beta-cell mass using the hyperglycaemic clamp test in insulin-independent pancreas-kidney recipients with that in non-diabetic kidney recipients and normal controls as well as with the partially previously reported data in beta-cell recipients.

Inclusion Criteria:

• kidney pancreas recipients
• kidney recipients
• healthy volunteers
• beta-cell recipients
• immunosuppression with MMF-Tacrolimus
• 1-4 years after transplantation

Exclusion Criteria:

• high doses of steroids
• insulin dependent