Purpose: Identification of the gene(s) involved in plasma membrane remodelling. Identification of the circulating markers affected by the defective membrane remodelling in a collection of families with unexplained provoked hemorrhages and evaluation of their prognosis value in the assessment of the hemostatic cellular response.Hypothesis: Scott syndrome is rare a familial disorder characterized by provoked haemorrages in homozygous-type patients due to isolated membrane remodelling deficiency. Membrane remodelling is necessary for cellular hemostatic responses.

Inclusion Criteria:

• Patients with unexplained provoked hemorrhages (surgery, tooth extraction, birth …), and associated with reduced prothrombin consomption (residual prothrombine in serum > à 5%).
• Family members of the patients defined above, with or without unexplained hemorrhages (symptomatic or not).
• Patient's approval based on detailed information given by the pratician

Exclusion Criteria:

• Patients with primary hemostasis defect or defective blood coagulation factor(s) possibly explaining the bleeding disorder.
• Anémia,
• patients known to be affected by Factor V New York .
• Patients enrolled in a previous clinical study, the exclusion period of which is not yet completed. - Collaboration to the study rejected by the patient
• Patients that are not registered for medical care social insurance.

Patients with unexplained bleeding disorder