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| ID | Type | Description | Link |
|---|---|---|---|
| 00173 |
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The purpose of this study is to evaluate how often patients with hepatitis C infection have abnormalities of sugar and fat utilization. Additionally we would like to find out if these abnormalities of sugar and fat utilization are common in other liver diseases, or related to being overweight.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 2 | No Intervention | One half of the patients will take not medication for 30 days and then have labs redrawn | |
| 1 | Experimental | one half of the patients with insulin resistance will take 4ml of 20% N-acetylcysteine BID for 30 days |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| N-acetylcysteine 20% 4ml | Drug | N-acetylcysteine 20% 4ml |
| |
| N-acetylcysteine 20% in 4 ml |
| Measure | Description | Time Frame |
|---|---|---|
| Those patients who are identified to have insulin resistance will be asked to participate in the treatment phase of the study | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| One half of patients with insulin resistance will undergo 30 day treatment with N-acetylcysteine to see if we can measure an improvement in fasting insulin and glucose levels | 2 years |
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Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Prashant K Pandya, DO | Kansas City VA Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kansas City VA Medical Center | Kansas City | Missouri | 64128 | United States |
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D000111 | Acetylcysteine |
| ID | Term |
|---|---|
| D003545 | Cysteine |
| D000603 | Amino Acids, Sulfur |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
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| Drug |
N-acetylcysteine 20% in 4 ml |
|
| D000596 |
| Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |