Chemotherapy and Proton Radiation for the Treatment of Locally Advanced Lung Cancer

Phase I/II Study of Combined Chemotherapy and High Dose, Accelerated Proton Radiation for the Treatment of Locally Advanced Non-Small Cell Lung Carcinoma

The purpose of this study is to determine the effectiveness of proton beam radiotherapy combined with chemotherapy for treatment of locally advanced non-small cell lung cancer.

Inclusion Criteria:

• Clinical stage 2, 3A or 3B (unresectable)
• Histologic evidence of non-small cell carcinoma
• Age > 18 years
• Karnofsky performance status 70 or greater
• No prior radiation to the chest
• No previous chemotherapy

Exclusion Criteria:

• Clinical stage 1 or 4
• Previous malignancies except for non-melanoma skin cancer unless disease free for > 3 years