Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| R21DA022424 | U.S. NIH Grant/Contract | View source | |
| R21DA022424-01A1 | U.S. NIH Grant/Contract | View source |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to explore the interaction between stress and marijuana cues, in hopes that it may lead to the development of new treatments for marijuana dependence.
Although use of marijuana is widespread, little research has focused on the treatment of marijuana use disorders or on predictors of relapse. Although several factors contributing to relapse have been explored in other dependencies (i.e., alcohol, cocaine), little research has focused on drug cue-related or stress-induced relapse in marijuana-dependent individuals. Cue reactivity is a construct measured in a laboratory procedure where an individual's subjective, behavioral, and physiological responses are assessed following exposure to drug-related environmental cues or stressors. Investigating the effects of drug-related environmental cues and stress in marijuana-dependent individuals will be useful in guiding treatment development.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stress + cue exposure | Experimental | Individuals were exposed to the Trier Social Stress Test (TSST) as well as neutral cues and marijana cues. |
|
| No stress + cue exposure | Experimental | Individuals were not exposed to a stress test, but were exposed to neutral cues and marijuana cues. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Stress + cue exposure | Other | Trier Social Stress Task(TSST): subject is asked to give a talk and perform a math task in front of an audience, follwed by neutral and marijuana cue exposure. |
| Measure | Description | Time Frame |
|---|---|---|
| Subjective Craving of Marijuana | Defined as the score on the Marijuana Craving Questionnaire (MCQ), range 7-84, higher scores indicate more craving | approx 2.5 hours (before, during and after exposure to stressor condition as well as exposure to neutral and marijuana-associated cues). |
| Measure | Description | Time Frame |
|---|---|---|
| Physiological Assessments: Serum Cortisol, ACTH, BP, HR, and GSR | ~ 2.5 hours (before, during and after exposure to stressor condition as well as exposure to neutral and marijuana-associated cues). | |
| Feelings of Stress/Anxiety as Measured by the State-Trait Inventory (STAI) |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Aimee L McRae, PharmD, BCPP | Medical University of South Carolina | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of South Carolina | Charleston | South Carolina | 29425 | United States |
Not provided
Participants were recruited primarily through community advertisements between January 2008 and June 2009.
Not provided
| ID | Title | Description |
|---|---|---|
| FG000 | Stress | Participants assigned to this group are required to complete the Trier Social Stress Task, which involves delivering a 5-minute speech and performing a 5-minute math problem in front of an audience. They then complete a cue exposure session involving both neutral and marijuana-related cues. |
| FG001 | No Stress | Participants assigned to this group are required to read magazines for ten minutes. They then complete a cue exposure session involving both neutral and marijuana-related cues. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
Not provided
Not provided
| ID | Title | Description |
|---|---|---|
| BG000 | Stress | Participants assigned to this group are required to complete the Trier Social Stress Task, which involves delivering a 5-minute speech and performing a 5-minute math problem in front of an audience. They then complete a cue exposure session involving both neutral and marijuana-related cues. |
| BG001 |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Subjective Craving of Marijuana | Defined as the score on the Marijuana Craving Questionnaire (MCQ), range 7-84, higher scores indicate more craving | Posted | Jul 2010 | Mean | Standard Deviation | Scores on a Scale | approx 2.5 hours (before, during and after exposure to stressor condition as well as exposure to neutral and marijuana-associated cues). |
|
Not provided
Not provided
Not provided
| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Stress | Participants assigned to this group are required to complete the Trier Social Stress Task, which involves delivering a 5-minute speech and performing a 5-minute math problem in front of an audience. They then complete a cue exposure session involving both neutral and marijuana-related cues. |
Not provided
Not provided
A control group of non-marijuana dependent individuals was not included, which may have provided further insight into the interactions of stress and cues both in the presence and absence of addiction.
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Aimee McRae-Clark, PharmD | Medical University of South Carolina | 843-792-5126 | mcraeal@musc.edu |
Not provided
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| ID | Term |
|---|---|
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
Not provided
Not provided
| ID | Term |
|---|---|
| D011581 | Psychological Tests |
| ID | Term |
|---|---|
| D004191 | Behavioral Disciplines and Activities |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| No stress + cue exposure | Other | Neutral and marijuana-associated cue exposure (scripted imagery, in vivo cues). |
|
|
| ~2 hours |
| Current Mood as Assessed by the Mood Form | ~2 hours |
| No Stress |
Participants assigned to this group are required to read magazines for ten minutes. They then complete a cue exposure session involving both neutral and marijuana-related cues. |
| BG002 | Total | Total of all reporting groups |
| Participants |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
|
|
| Secondary | Physiological Assessments: Serum Cortisol, ACTH, BP, HR, and GSR | Not Posted | ~ 2.5 hours (before, during and after exposure to stressor condition as well as exposure to neutral and marijuana-associated cues). |
| Secondary | Feelings of Stress/Anxiety as Measured by the State-Trait Inventory (STAI) | Not Posted | ~2 hours |
| Secondary | Current Mood as Assessed by the Mood Form | Not Posted | ~2 hours |
| 0 |
| 45 |
| 0 |
| 45 |
| EG001 | No Stress | Participants assigned to this group are required to read magazines for ten minutes. They then complete a cue exposure session involving both neutral and marijuana-related cues. | 0 | 42 | 0 | 42 |
Not provided
Not provided