Near Normalisation of BG Improves the Potentiating Effect of GLP-1

Near Normalisation of Blood Glucose Improves the Potentiating Effect of GLP-1 on Glucose Induced Insulin Secretion in Patients With Type 2 Diabetes

The ability of glucagon-like peptide 1 to enhance beta-cell responsiveness to I.v. glucose is impaired in patients with type 2 diabetes mellitus compared with healthy individuals. We investigated whether 4 weeks of near-normalisation og blood glucose improves the potentiation of glucose-stimulated insulin secretion by GLP-1

Inclusion Criteria:

• Age 18-70 years
• Type 2 diabetes diagnosed after 30 years of age
• BMI > 25

Exclusion Criteria:

• Severe complications to diabetes
• Abnormal liver og kidney function
• Haemoglobin below the lower limit
• Macroalbuminuria
• Systemic disease
• Pregnancy