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| ID | Type | Description | Link |
|---|---|---|---|
| E-07/2007 | |||
| 2007DR1251 |
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| Name | Class |
|---|---|
| Psychiatric University Hospital, Zurich | OTHER |
| H. Lundbeck A/S | INDUSTRY |
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This study aims to further validate and extend our previous findings insofar that the effect of the atypical antipsychotic and mixed 5-HT2/D2 antagonist sertindole on sensorimotor gating processes and its relationship to cognitive performance shall be explored.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 2 | Experimental | Healthy volunteers with high sensory gating levels. |
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| 1 | Experimental | Healthy volunteers with low sensory gating levels. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sertindole | Drug | oral 3 x 4mg |
| |
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Sensory (EEG: P50 suppression) and sensorimotor gating (EMG: PPI) | after placebo and and after medical treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive performances | after placebo and and after medical treatment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Franz X. Vollenweider, Prof. Dr. med. | University Hospital of Psychiatry, Department Neuropsychopharmacology and Brain Imaging | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Psychiatry Hospital | Zurich | Canton of Zurich | CH-8032 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21890590 | Result | Holstein DH, Csomor PA, Geyer MA, Huber T, Brugger N, Studerus E, Vollenweider FX. The effects of sertindole on sensory gating, sensorimotor gating, and cognition in healthy volunteers. J Psychopharmacol. 2011 Dec;25(12):1600-13. doi: 10.1177/0269881111415734. Epub 2011 Sep 2. |
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| ID | Term |
|---|---|
| C066304 | sertindole |
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| Drug |
3 x 4mg Placebo |
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