The Effect of Sertindole on Sensory Gating and Cognition in Healthy Volunteers

This study aims to further validate and extend our previous findings insofar that the effect of the atypical antipsychotic and mixed 5-HT2/D2 antagonist sertindole on sensorimotor gating processes and its relationship to cognitive performance shall be explored.

Inclusion Criteria:

• Age: 18-40
• Gender: male

Exclusion Criteria:

• Axis I Disorders: lifetime DSM IV diagnosis according to DIA-X of alcohol or illicit drug dependence. No life-time DSM IV diagnosis according to DIA-X of a major affective, psychotic, anxiety disorder, eating-disorder as defined above.
• Axis II Disorders: lifetime DSM IV diagnosis of personality disorder according to SCID-II.
• Family history: lifetime history of 1st degree relative (parents and siblings) of a major affective, psychotic, or anxiety disorder as defined above.
• ECG: QTc-interval >450 msec.
• Systolic blood pressure <100 mmHg
• Bradycardia (Hf < 50/Min) und Arrhythmias
• Hypokalemia or Hypomagnesemia