Split Dose Golytely With Amitiza Pretreatment Versus Split Dose Golytely Plus Placebo in Outpatient Colonoscopy

Single Dose Lubiprostone Along With Split-dose PEG Solution Without Dietary Restrictions for Bowel Cleansing Prior to Colonoscopy, a Randomized, Double-blind, Placebo Controlled Trial

The primary outcomes of this procedure will be: 1. The cleanliness of the prep as measured by the Ottawa Scale (attachment a). Secondary outcomes will be: 1. Patient satisfaction with the prep measured by 5 point Likert scale (attachment b); 2. Procedure time; 3. The number and size of polyps detected on examination.

Inclusion Criteria:

• Adult patients referred to our clinic for Average or Increased Risk screening for Colorectal Cancer
• Ages will be from 18 years of age and older

Exclusion Criteria:

• Chronic kidney disease
• Previous diagnosis of congestive heart failure
• History of bowel obstruction
• History of solid organ transplant
• Pregnancy