1. Although after treatment for breast cancer such as chemotherapy or hormonal therapy, urogenital atrophy is common, the patients are seldomly treated for several reasons. Management of this problem is important for improving quality of life.
2. "Clino-san" is a kind of vaginal lubricant with pH 5 which is similar pH of premenopausal vaginal discharge. After randomization of patients, they are treated with Clino-san or placebo 3 times/week for 12 weeks.
3. We check the vaginal symptoms, vag dryness severity score, and ultrasonography at baseline, 4, 8, and 12 weeks of treatment.

Inclusion Criteria:

• breast cancer patients
• who are treated with chemotherapy or hormonal therapy
• who experience no menstruation after the previous therapy
• who complain of vaginal dryness

Exclusion Criteria:

• other cancer patients
• other severe disease
• poor compliance