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Adhesive small intestine obstruction (ASIO) is an important cause of hospital admission and a very common disease. Any improvement in this field will benefit many patients by reducing the operative rate. Patients with this disease are difficult to evaluate and to manage and their treatment is controversial. Emergency surgery is mandatory when strangulation is suspected or in the case of total obstruction. On the other hand, conservative non-operative treatment is indicated in the case of partial obstruction. The role of water-soluble contrast medium (Gastrografin®: GG) in ASIO is still debated with regard to the therapeutic value.
The aim of our study was to determine the therapeutic role of Gastrografin in patients with small intestine obstruction without strangulation caused by adherences (ASIO).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GG | Experimental |
| |
| TT | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| traditional conservative treatment (TT) | Other | In the control group (TT: Traditional Treatment), the patients have been treated as in our daily surgical practice of traditional conservative treatment for ASIO, consisting in nil per os diet, nasogastric tube (NGT) decompression and intravenous fluid resuscitation therapy with electrolytes imbalances correction. |
| Measure | Description | Time Frame |
|---|---|---|
| The operative rate in ASIO patients | Within 72 hours and during hospital stay |
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of major and minor complications of treatments in the two arm | 1 year | |
| The ASIO recurrences | 1 year | |
| The time to resolution of obstruction |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Fausto Catena, MD, PhD | S.Orsola-Malpighi University Hospital - University of Bologna | Principal Investigator |
| Luca Ansaloni, MD | S.Orsola-Malpighi University Hospital - University of Bologna | Principal Investigator |
| Margherita Gavioli, MD | University of Modena and Reggio Emilia | Principal Investigator |
| Salomone Di Saverio, M.D. | S.Orsola-Malpighi University Hospital - University of Bologna | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| S.Orsola-Malpighi University Hospital - University of Bologna | Bologna | Italy | ||||
| Emergency Surgery Department - University of Modena |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18688562 | Derived | Di Saverio S, Catena F, Ansaloni L, Gavioli M, Valentino M, Pinna AD. Water-soluble contrast medium (gastrografin) value in adhesive small intestine obstruction (ASIO): a prospective, randomized, controlled, clinical trial. World J Surg. 2008 Oct;32(10):2293-304. doi: 10.1007/s00268-008-9694-6. |
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| ID | Term |
|---|---|
| D062407 | Meals |
| ID | Term |
|---|---|
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |
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| Gastrografin®: G | Drug | The study group (GG: Gastrografin Group) received, beyond the traditional conservative treatment for ASIO above mentioned, a G meal with a follow-through study immediately. |
|
|
| Within hospital stay |
| The length of hospital stay | Within hospital admission period |
| Modena |
| Italy |