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| Name | Class |
|---|---|
| Brigham and Women's Hospital | OTHER |
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This research study is being done because patients with a history of chest radiation treatment for Hodgkin's disease have been shown to be at increased risk for developing lung cancer a number of years out from treatment. The risk appears to be further increased among patients with a smoking history. Currently, the practice is to recommend annual low-dose chest CT scans in survivors of Hodgkin's disease who have received prior chest radiation treatment and who have at least a moderate smoking history. In this study, the CT scans will be read and interpreted by the study radiologist, and the results recorded in a consistent manner.
- Participants will undergo a chest computed tomography (CT) scan once a year for a 3-year period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low-dose Chest CT screening | Experimental | Annual low-dose Chest CT screening |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| chest computed tomography scan | Procedure | Once a year for three years |
|
| Measure | Description | Time Frame |
|---|---|---|
| To Prospectively Collect Data on Chest CT Screening for Patients at Increase Lung-cancer Risk After Hodgkin's Disease. | In this study, patients will under annual low-dose chest CT screening. The total number of lung cancer detected through the screening will be recorded | 3 years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Andrea K. Ng, MD | Dana-Farber Cancer Institute/Brigham and Women's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | United States | ||
| Dana-Farber Cancer Institute |
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| ID | Title | Description |
|---|---|---|
| FG000 | Low-dose CT Screening | Annual low-dose chest CT screening |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Low-dose CT Screening | Annual low-dose chest CT screening |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | To Prospectively Collect Data on Chest CT Screening for Patients at Increase Lung-cancer Risk After Hodgkin's Disease. | In this study, patients will under annual low-dose chest CT screening. The total number of lung cancer detected through the screening will be recorded | Enrolled patients who underwent low-dose CCT screening- number of lung cancer diagnosed | Posted | Number | participants | 3 years |
|
|
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Low-dose CT Screening | Annual low-dose chest CT screening |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Andrea Ng | DFCI | 617-732-6310 | ang@lroc.harvard.edu |
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| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| D006689 | Hodgkin Disease |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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Single arm study of low-dose Chest CT screening for long-term Hodgkin lymphoma survivors
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| Boston |
| Massachusetts |
| 02115 |
| United States |
| Participants |
|
| Age, Continuous | Mean | Full Range | years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
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|
| 0 |
| 39 |
| 0 |
| 39 |
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| D008171 |
| Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D008223 | Lymphoma |
| D009370 | Neoplasms by Histologic Type |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |