Serbian Smoking Reduction/Cessation Trial (2SRT)

Randomized, Placebo-controlled, Double-blind, Phase IV Trial to Assess the Efficacy of a Traditional Swedish Smokeless Tobacco Product ("Snus") to Reduce or Replace Cigarette Smoking Among Adult Smokers in Serbia

The study aims to establish if a low-nitrosamine, smokeless tobacco product (Swedish snus) can help adult smokers to reduce and eventually completely quit smoking.

Inclusion Criteria:

• Male and female smokers in good general health aged 20-65 years regularly smoking >10 cigarettes per day for more than 1 year who are motivated to reduce or quit smoking

Exclusion Criteria:

• Subjects with uncontrolled hypertension, history of coronary heart disease or other significant heart condition
• History of other significant medical condition that might interfere with study procedures
• Pregnant or nursing mother
• Current drug abuse.