Tigecycline for Treatment of Rapidly Growing Mycobacteria

Use of Tigecycline for Treatment of Serious Infection Due to Rapidly Growing Mycobacteria (Especially M.Abscessus)

To determine the safety, tolerance, and efficacy of Tigecycline when given daily to patients with rapidly growing mycobacterial disease (especially M.abscessus).

To assess the safety and efficacy of tigecycline in the treatment of drug resistant rapidly growing mycobacterial disease especially M. abscessus

Inclusion Criteria:

• Positive cultures for rapidly growing mycobacteria
• Patients who have drug resistant isolates or are intolerant of macrolides or have serious infections unresponsive to currently available drugs
• Adults and children 10 years of age and older
• Pretreatment isolate of M. avium complex available for MIC determination
• Available for followup appointments

Exclusion Criteria:

• History of tetracycline allergy
• If a menstruating female, not pregnant and on adequate birth control