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| ID | Type | Description | Link |
|---|---|---|---|
| 06-02-D-011 |
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The aim of the present prospective study is to investigate whether the consumption of certain probiotic strains over a six-month winter/spring season would be able to affect the incidence and duration of upper respiratory tract infections, in otherwise healthy children as well as determining whether a combination of two strains would perform differently from a single strain version.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Placebo Comparator | Placebo |
|
| Active 1 | Active Comparator | One probiotic strain |
|
| Active 2 | Active Comparator | Blend of two strains |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Dietary Supplement | Inert excipient |
| |
| Lactobacillus acidophilus NCFM |
| Measure | Description | Time Frame |
|---|---|---|
| To examine if the consumption of two different probiotic strains added to milk at the point of consumption could reduce the "flu-like" symptoms and other symptoms of illness of preschool-age children in day care centers. | Daily for six months |
| Measure | Description | Time Frame |
|---|---|---|
| To determine if children who consume a beverage fortified with a probiotic miss fewer days of preschool as measured by illness. | Six months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Charlie Zhang | Sprim Advanced Life Sciences | Study Director |
| Cheryl Riefer | Sprim Advanced Life Sciences | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Day care center | Jinhua | Zhejiang | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19651563 | Derived | Leyer GJ, Li S, Mubasher ME, Reifer C, Ouwehand AC. Probiotic effects on cold and influenza-like symptom incidence and duration in children. Pediatrics. 2009 Aug;124(2):e172-9. doi: 10.1542/peds.2008-2666. Epub 2009 Jul 27. |
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| Dietary Supplement |
1e10 CFU/day |
|
| Combination of Lactobacillus acidophilus and Bifidobacterium lactis | Dietary Supplement | 1x10e10 CFU/day |
|