Azithromycin in the Treatment of M. Avium Complex Lung Disease

Open, Noncomparative Trial of Azithromycin in the Treatment of M.Avium Complex (MAC) Lung Disease

To determine the safety and efficacy of azithromycin in the treatment of lung infection with M.avium complex and M. abscessus lung disease.

To study the safety and efficacy of azithromycin in combination treatment for M. abscessus and MAC lung disease

Inclusion Criteria:

• Meet American Thoracic Society criteria for nontuberculous lung disease: two or more AFB smear positive, culture positive sputums or bronchoscopic samples and/or two or more AFB smear negative respiratory samples with moderate to heavy growth (2+-4+); abnormal CXR consistent with M. avium lung disease; abnormal CXR consistent with M. avium lung disease; absence of other lung pathogens (except for the coexistence of M. abscessus).
• Age 18 and older
• Pretreatment isolate of M. avium complex available for MIC determination

Exclusion Criteria:

• History of macrolide allergy
• Received macrolide therapy in last two months
• Children less than 18 years of age
• If a menstruating female, not pregnant and on adequate birth control