Preoperative Chemoradiation Versus Short Term Radiation Alone With Delayed Surgery for Stage II and III Resectable Rectal Cancer

Preoperative Chemoradiation Versus Short Term Radiation Alone With Delayed Surgery for Stage II and III Resectable Rectal Cancer

Trial compares two preoperative stage II and III rectal cancer treatment strategies: short term radiotherapy 5x5 Gy and delayed surgery after 6 weeks versus conventional chemoradiotherapy 50 Gy + 5Fu/Lv and surgery also after 6 weeks.

Inclusion Criteria:

• histologically confirmed stage II and III rectal cancer less than 15 cm from anal verge
• less than 80 years old
• no other cancer during 5 years period
• compensate cardiovascular, pulmonary, hepatic and renal functions.

Exclusion Criteria:

• stage I or IV rectal cancer
• other cancer in 5 years period
• radiotherapy or chemotherapy in anamnesis
• not compensate cardiovascular, pulmonary, hepatic or renal functions, neurological, psychiatric disease, sepsis, etc.
• pregnancy or baby feeding