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| ID | Type | Description | Link |
|---|---|---|---|
| 137/2006 |
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Trial compares two preoperative stage II and III rectal cancer treatment strategies: short term radiotherapy 5x5 Gy and delayed surgery after 6 weeks versus conventional chemoradiotherapy 50 Gy + 5Fu/Lv and surgery also after 6 weeks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | preoperative short term radiation group 5x5 Gy and surgery after 6 weeks |
|
| 2 | Experimental | preoperative chemoradiotherapy group 50Gy + 5FU/Lv and surgery after 6 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| radiotherapy | Radiation |
|
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| Measure | Description | Time Frame |
|---|---|---|
| 5 years overall and disease free survival | 5 years | |
| recurrence rate | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| pathological "complete response" and downstaging rates | 5 years | |
| Impact on sphincter sparing operation rates | 5 years | |
| morbidity and mortality rates |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tadas Latkauskas | Contact | +370 676 08901 | tadas.latkauskas@kmuk.lt |
| Name | Affiliation | Role |
|---|---|---|
| Dainius Pavalkis, professor | Kaunas Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| KMUH, surgery department | Recruiting | Kaunas | LT3000 | Lithuania |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27903247 | Derived | Latkauskas T, Pauzas H, Kairevice L, Petrauskas A, Saladzinskas Z, Janciauskiene R, Gudaityte J, Lizdenis P, Svagzdys S, Tamelis A, Pavalkis D. Preoperative conventional chemoradiotherapy versus short-course radiotherapy with delayed surgery for rectal cancer: results of a randomized controlled trial. BMC Cancer. 2016 Dec 1;16(1):927. doi: 10.1186/s12885-016-2959-9. |
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| ID | Term |
|---|---|
| D012004 | Rectal Neoplasms |
| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
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| ID | Term |
|---|---|
| D011878 | Radiotherapy |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
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| 5 years |
| Impact on quality of surgical resection | 5 years |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |